PCN-527 Topic 4 DQ 1

Topic 4 DQ 1

The text (page 106) describes the phenomenon of "therapeutic index." Addiction to barbiturates can be critical in terms of lethality as measured by the therapeutic index. Provide an example, which explains how this phenomenon might lead to an accidental overdose. Why is this factor more critical with barbiturates than with other classes of depressant drugs? 
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